Disseminated adenovirus infection in a 10-year-old renal allograft recipient

Disseminated adenovirus infection in a 10-year-old renal allograft recipient

Blog Article

Disseminated adenovirus infection can result in high mortality and morbidity in immunocompromised patients.Here, we report the case of a 10-year-old renal allograft recipient who presented with hematuria and dysuria.Adenovirus was isolated from his Action Figure urine.

His urinary symptoms decreased after intravenous hydration and reduction of immunosuppressants.However, 2 weeks later he presented with general weakness and laboratory tests indicated renal failure necessitating emergency hemodialysis.Adenovirus was detected in his sputum; therefore, intravenous ganciclovir Creator T-Shirt and immunoglobulin therapy were initiated.

Renal biopsy revealed diffuse necrotizing granulomatous tubulointerstitial nephritis compatible with renal involvement of the viral infection.Adenovirus was detected in his serum.Despite cidofovir administration for 2 weeks, adenovirus was also detected in the cerebrospinal fluid, resulting in generalized tonic-clonic seizure.

The patient died 7 weeks after the onset of urinary symptoms.Adenovirus should be considered in screening tests for post-renal transplantation patients who present with hemorrhagic cystitis.